Sepsis is a life-threatening condition and continues to have a high morbidity and mortality. Developing an understanding of early sepsis recognition, applying the appropriate treatment in a timely manner can help save lives. Nurses are essential in early recognition and early treatment. The most current 2021 Surviving Sepsis Campaign (SSC) Guidelines are useful in providing recommendations and rationale for treatment. Also new to the 2021 guidelines is a section on long-term outcomes and goals of care. As more and more individuals survive sepsis, resources to aid in their recovery are needed to improve long-term outcomes. This talk is relevant for individuals who care for patients with sepsis and septic shock and is a core measure for the Centers of Medicare and Medicaid. Nurses can make a difference in the lives of patients with sepsis and in the process improve compliance with the performance measure as well.